Human leukocyte antigen (HLA) system is a gene complex encoding the major histocompatibility complex proteins in humans. These cell-surface proteins are responsible for the regulation of the immune system.
HLAB27 is crucial for diagnosis of ankylosing spondylitis (AS) and AS related Spondylarthropathy. HLAB27 takes an important role in disease pathogenesis and there are several types of the disease. The prevalence of the disease is altering between different ethnic groups.
HLA-B 57:01 is a genetic variation linked to hypersensitivity to the antiretroviral (ARV) drug Abacavir. Combination ARV therapy (cART) is an effective treatment strategy for HIV infections and it decreases morbidity and mortality rates for HIV-infected patients. Abacavir (ABC) is a guanosine analog and it is a reverse transcriptase inhibitor. The drug has been approved by US Food and Drug Administration (FDA) since 1998 and it is used in combination with other ARV drugs (1,2).
1. Stocchi, L., Cascella, R., Zampatti, S., Pirazzoli, A., Novelli, G. and Giardina E., The Pharmacogenomic HLA Biomarker Associated to Adverse Abacavir Reactions: Comparative Analysis of Different Genotyping Methods, Current Genomics, 2012, 13, 314-320.
2. Dello Russo, Lisi, Fabbiani et al., Detection of HLA-B*57:01 by real-time PCR: implementation into routine clinical practice and additional validation data, Pharmacogenomics (2014) 15(3), 319–327
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